An antineoplastic of Rhodomycin group; Antibiotic; Inhibitor of enzymes and metabolic pathways. A potent anticancer agent that has been shown to be a strong inhibitor of DNA and RNA synthesis.
- Presentation: Powder
- LD50 in mice 26 mg/kg in vitro.
- Soluble in water, methanol, aqueous alcohols. Practically insoluble in chloroform, ether, benzene.
Daunorubicin hydrochloride is used in photostability , antileukemic, and drug metabolism studies.
Daunorubicin inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent. On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunomycin effectively binds to every 3 base pairs which causes unwinding.
LD50 in mice 26 mg/kg in vitro.
Soluble in water, methanol, aqueous alcohols and insoluble in chloroform, ether, benzene
Caution: Protect from light