2,6-Di-tert-butyl-p-cresol, crystalline powder


Synonyms: 2,6-Di-tert-butyl-4-methylphenolButylhydroxytolueneButylated hydroxytolueneBHT

0210116280 0210116291 0210116290
IC10116290EA 54.56 USD
IC10116290 IC10116280 IC10116291
2,6-Di-tert-butyl-p-cresol, crystalline powder

Butylated hydroxytoluene is a phenolic antioxidant.

Butylated hydroxytoluene (BHT) has been shown to inhibit lipid peroxidation. It causes lung injury and promotes tumors in mice, but this may be due to a metabolite of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-methylphenol. Metabolites of BHT have also been reported to induce DNA strand breaks and internucleosomal DNA fragmentation (a characteristic of apoptosis) in cultured cells. In rats, a single intraperitoneal injection of BHT (60 mg/kg body mass) results in a significant increase in nuclear DNA methyl transferase activity in the liver, kidneys, heart, spleen, brain and lungs. Incubation of alveolar macrophages with BHT significantly reduced the level of TNF-α which may explain the mechanism by which this antioxidant reduces inflammation. Preincubation of aspirin-treated platelets with BHT inhibits the secretion, aggregation, and protein phosphorylation induced by protein kinase C activators. BHT was also found to inhibit the initiation of hepatocarcinogenesis by aflatoxin B1.

Insoluble in water; Freely soluble in toluene, soluble in methanol, ethanol (100 mg/mL), isopropanol, methyl ethyl ketone, acetone, Cellosolve, benzene and most other hydrocarbon solvents. More soluble in food oils and fats than butylated hydroxyanisole.

Caution: Research Use Only (RUO).

Formula: C₁₅H₂₄O
MW: 220.35 g/mol
Storage Temperature: Ambient
MDL Number: MFCD00011644
CAS Number: 128-37-0

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Specification Test Results

Identity Test Passes
FTIR Conforms to Standard
Melting Point 68 - 74 °C

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