2,6-Di-tert-butyl-p-cresol, crystalline powderSupplier: MP BIOMEDICALS (FKA ICN BIOMED
, Butylated hydroxytoluene
Butylated hydroxytoluene is a phenolic antioxidant.
Butylated hydroxytoluene (BHT) has been shown to inhibit lipid peroxidation. It causes lung injury and promotes tumors in mice, but this may be due to a metabolite of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-methylphenol. Metabolites of BHT have also been reported to induce DNA strand breaks and internucleosomal DNA fragmentation (a characteristic of apoptosis) in cultured cells. In rats, a single intraperitoneal injection of BHT (60 mg/kg body mass) results in a significant increase in nuclear DNA methyl transferase activity in the liver, kidneys, heart, spleen, brain and lungs. Incubation of alveolar macrophages with BHT significantly reduced the level of TNF-α which may explain the mechanism by which this antioxidant reduces inflammation. Preincubation of aspirin-treated platelets with BHT inhibits the secretion, aggregation, and protein phosphorylation induced by protein kinase C activators. BHT was also found to inhibit the initiation of hepatocarcinogenesis by aflatoxin B1.
Insoluble in water; Freely soluble in toluene, soluble in methanol, ethanol (100 mg/mL), isopropanol, methyl ethyl ketone, acetone, Cellosolve, benzene and most other hydrocarbon solvents. More soluble in food oils and fats than butylated hydroxyanisole.
Caution: Research Use Only (RUO).
MW: 220.35 g/mol
Storage Temperature: Ambient
CAS Number: 128-37-0
Specification Test Results
|FTIR||Conforms to Standard|
|Melting Point||68 - 74 °C|
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