Polymyxin B sulphate, powder

Supplier: MP BIOMEDICALS (FKA ICN BIOMED

0210056501 0210056505 0210056510 0210056550 0210056525
IC10056550EA 771.91 USD
IC10056550 IC10056501 IC10056510 IC10056505 IC10056525
Polymyxin B sulphate, powder
Polymyxin B sulphate

Polymyxin B Sulfate is a mixture of Polymyxin B1 and Polymyxin B2 Sulfate, obtained from Bacillus polymyxia strains


  • Presentation: White Powder
  • Soluble in water, 1 mM HCl


Polymyxin B sulfate is a mixture of Polymyxin B1 and B2 sulfate. It is used clinically to treat infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. It is used to study multidrug-resistant pathogens.


Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.


Polymyxin B inhibits gram-negative organisms in vitro wherein it binds to and interferes with the permeability of the bacterial cytoplasmic membrane and is also reported to inhibit Ca2+ dependent protein kinase C (PKC).

Formula: C₅₅H₉₆N₁₆O₁₃·2H₂SO₄
MW: 1385.61 g/mol
Storage Temperature: Refrigerator
MDL Number: MFCD00131991
CAS Number: 1405-20-5
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Specification Test Results

FTIR Conforms to Standard
pH (1% aq soln) 5-7
Loss on Drying ≤8%

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