Streptozocin ≥97% (~75% α-anomer basis), off-white powder


Synonyms: Streptozotocin

0210055701 02100557.1 02100557.5 02100557.6 0210055705
IC100557.6EA 42.63 USD
IC100557.6 IC100557.1 IC10055701 IC100557.5 IC10055705
Streptozocin ≥97% (~75% α-anomer basis), off-white powder

Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.

  • Extinction Coefficient (E1%): EmM(228 nm): 6.36 (ethanol)
  • Biological half-life in cell culture medium was shown to be approximately 19 minutes.

Streptozocin is used to induce Type 1 diabetes for medical research. It has been used for the treatment of malignant insulinoma It is used mainly in the treatment of pancreatic (islet-cell) tumors.

An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.

Soluble in water (50 mg/mL - clear to slightly hazy, light yellow solution) and ethanol.

Formula: C₈H₁₅N₃O₇
MW: 265.2 g/mol
Melting Pt: 121 °C (dec., lit.)
Storage Temperature: Freezer
MDL Number: MFCD00006607
CAS Number: 18883-66-4

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Specification Test Results

Identity Test Passes
Purity ≥97%
Alpha Anomer ≥75.0%
FTIR Conforms to Standard

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