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Iodoacetamide, tan powder

Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Danger

0210035105 0210035125 0210035110 0210035191 0210035180
Iodoacetamide is a thiol reagent; alkylating reagent for cysteine and histidine residues in proteins. In the alkylation reaction, it reacts with histidine (such as in RNase), methionine and sulfhydryl groups of many proteins.

Iodoacetamide can react with low molecular weight thiol compounds such as mercaptoethanol and glutathione. The reaction with glutathione is utilized in a titration method for the determination of sulfhydryl groups in different compounds. The alkylation reaction forms stable protein derivatives which will remain intact during further study of the protein.

Iodoacetamide is useful in peptide sequencing and as an irreversible enzyme inhibitor. Some enzymes iodoacetamide will inhibit include (but is not limited to): Alcohol dehydrogenase, Alkaline phosphatase (calf intestinal), beta-Amylase, Cathepsin B, Galactose oxidase, Heme oxygenase, L-Lysine decarboxylase. It will irreversibly inhibit the dephosphorylation of both epidermal growth factor receptor and platelet-derived growth factor receptor by alkylation at the active center of one or several protein tyrosine phosphatases in cell lines. Iodoacetamide will also irreversibly inhibit many cysteine proteases. Alkylating reagent for cysteine residues in peptide sequencing. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibition of ribonuclease.

Soluble in water (recommended stock solution is 10-100 mM). All solutions should be prepared fresh for each use since solutions are very light sensitive.


Formula: ICH₂CONH₂
MW: 184,96 g/mol
MDL Number: MFCD00008028
CAS Number: 144-48-9
UN: 2811
ADR: 6.1,III


 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
5 g 0210035105 IC10035105 Each (5g) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

10 g 0210035110 IC10035110 Each (10g) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

25 g 0210035125 IC10035125 Each (25g) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

100 g 0210035180 IC10035180 Each (100g) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

1 kg 0210035191 IC10035191 Each (1kg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

restricted In order to process your orders without delay, we request that you provide the required business documentation to purchase this product.

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* Please note if your account is within the State of California two of these pieces of identification will be required.
VWR will not lift restrictions for residential shipping addresses.

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