EIF2AK3(Eukaryotic translation initiation factor 2-alpha kinase 3) is also named as PEK, PERK and belongs to the GCN2 subfamily. It acts potentially as a metabolic sensor in the insulin-secreting beta-cells to modulate the trafficking and quality control of proinsulin in the ER relative to the physiological demands for circulating insulin. EIF2AK3and EIF2AK4 also have a functional role on regulating translation under non-stressed conditions, apart from their long established roles as stress kinases. The full length protein has a signal peptide and a glycosylation site.
IHC: Human pancreas Tissue, 1:20-1:200; Western Blot: HeLa Cells, 1:200-1:2000
Type: Primary
Antigen: EIF2AK3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human