Anti-SPRED2 Rabbit Polyclonal Antibody

Supplier: Proteintech
10095-122EA 402 USD
Anti-SPRED2 Rabbit Polyclonal Antibody
SPRED2 is a member of the SPRED family of proteins that modulate growth factor receptor signaling by inhibiting the Ras-MAPK cascade . SPRED family members are characterized by an N-terminal Enabled/VASP homology 1 domain (EVH1), a central c-Kit binding domain (KBD) and a C-terminal Sprouty-related domain (SPR) . Three mammalian SPREDs (SPRED1-3) have been described. In adult tissues, SPRED2 is expressed ubiquitously, but most highly expressed in glandular epithelia . Reduced expression level of SPRED2 has been reported in human hepatocellular carcinoma (HCC), suggesting SPRED2 may play a role in tumorgenesis . Gene disruption of SPRED2 causes dwarfism .

Western Blot: Mouse Testis Tissue, 1:500-1:5000; IHC: Human Testis Tissue, 1:20-1:200

Type: Primary
Antigen: SPRED2
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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