Anti-DR4 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-DR4 Rabbit Polyclonal Antibody

Anti-DR4 Rabbit Polyclonal Antibody

24063-1-AP-150UL

10086-112EA 402 USD

10086-112

Anti-DR4 Rabbit Polyclonal Antibody

Antibodies

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily. TRAIL activates apoptosis through the death receptors DR4 (also known as TRAILR1 and TNFRSF10A) and DR5 (also known as TRAILR2, KILLER and TNFRSF10B). DR4 and DR5 are single-pass type I membrane proteins that contain intracellular death domains (DD) and upon activation mediate apoptotic signals . Binding of TRAIL to DR4 or DR5 results in receptor oligomerization and recruitment of FAS-associated protein with death domain (FADD) and caspase 8 to form a functional death-inducing signalling complex (DISC). Upon DISC formation, caspase 8 is cleaved and activated, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis . DR4 or DR5 promotes the activation of NF-kappa-B and play an important role in inflammation .

Western Blot:Jurkat Cells, 1:500-1:5000

Type: Primary
Antigen: DR4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human

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