Anti-TNFAIP3 Rabbit Polyclonal Antibody

Supplier: Proteintech
10096-120EA 402 USD
Anti-TNFAIP3 Rabbit Polyclonal Antibody
TNFAIP3, also named A20, is a cytoplasmic zinc finger protein that inhibits nuclear factor kappa-B (NFKB) activity and tumor necrosis factor (TNF)-mediated programmed cell death. A20 is a ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities, and involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Upon T- or B-cell receptor engagement human (h) A20 is cleaved by MALT1 after arginine 439, yielding an N-terminal fragment and a C-terminal one (~37-40kDa). This antibody, which is a rabbit polyclonal antibody raised against 350 a.a of C-terminus of human TNFAIP3 antigen, can recognize total A20(~90kDa) and cleavage form(~37-40kDa).

Western Blot: RAW 264.7 Cells, 1:200-1:2000

Type: Primary
Antigen: TNFAIP3
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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