Anti-PHLPP Rabbit Polyclonal Antibody

Supplier: Proteintech
10092-210EA 537.7 USD
Anti-PHLPP Rabbit Polyclonal Antibody
PHLPP, also named as KIAA0931, PHLPPL, is a 1323 amino acid protein, which contains 22 LRR (leucine-rich) repeats, 1 PH domain and 1 PP2C-like domain. PHLPP expression is concentrated in the cytoplasm and nucleus. In colorectal cancer tissue, PHLPP expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but it is largely excluded from the crypt bases. PHLPP uses manganese as a cofactor and mediates the dephosphorylation of Akt1, thereby playing a role in cell survival and apoptotic regulation.

Western Blot: Mouse Brain Tissue, 1:500-1:5000; IF: HepG2 Cells, 1:20-1:200; IHC: Human Liver Tissue, 1:20-1:200; IP: Mouse Brain Tissue, 1:500-1:5000

Type: Primary
Antigen: PHLPP
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
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