Anti-AIRE Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-AIRE Rabbit Polyclonal Antibody

Anti-AIRE Rabbit Polyclonal Antibody

Anti-AIRE Rabbit Polyclonal Antibody

Anti-AIRE Rabbit Polyclonal Antibody

Anti-AIRE Rabbit Polyclonal Antibody

Anti-AIRE Rabbit Polyclonal Antibody

22517-1-AP-150UL

10082-644EA 462.47 USD

10082-644

Anti-AIRE Rabbit Polyclonal Antibody

Antibodies

The function of the protein is not well defined, however it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described [1]. The longer AIRE1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE3 includes the same exon 1-8-9 sequences as found in AIRE2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized. The resulting protein products of these splice variants differ significantly. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

Western Blot:L02 Cells, 1:500-1:5000; IHC: Human Stomach Tissue, 1:20-1:200

Type: Primary
Antigen: AIRE
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse

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