Anti-BRCA1 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-BRCA1 Rabbit Polyclonal Antibody

Anti-BRCA1 Rabbit Polyclonal Antibody

22362-1-AP-150UL

10081-980EA 402 USD

10081-980

Anti-BRCA1 Rabbit Polyclonal Antibody

Antibodies

BRCA1, also named as RNF53, plays a central role in DNA repair by facilitating cellular response to DNA repair. It is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. BRCA1 acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. It is involved in transcriptional regulation of P21 in response to DNA damage. BRCA1 is required for FANCD2 targeting to sites of DNA damage. It may function as a transcriptional regulator. BRCA1 inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. The antibody is specific to BRCA1.

Western Blot: HeLa Cells, 1:500-1:5000; IHC: Human breast cancer Tissue, 1:20-1:200

Type: Primary
Antigen: BRCA1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human

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