ATXN2 contains a repeat structure with 22 or 23 triplets coding for glutamine and the (CAG)8CAA(CAG)4CAA(CAG)8 sequence; expansion of this domain to a size ≥34 triplets with a pure CAG sequence primarily causes autosomal dominant SCA2 , while ATXN2 expansions with CAA interruptions were observed as the cause of Levo-dopa responsive Parkinson’s disease . ATXN2 expansions associated with ALS were reported to be interrupted by at least one CAA triplet .
IHC: Human gliomas Tissue, 1:20-1:200; IF: HepG2 Cells, 1:10-1:100; Western Blot: HeLa Cells, 1:500-1:5000
Type: Primary
Antigen: ATXN2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat