Anti-SMC1A Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-SMC1A Rabbit Polyclonal Antibody

Anti-SMC1A Rabbit Polyclonal Antibody

21695-1-AP-150UL

10094-872EA 402 USD

10094-872

Anti-SMC1A Rabbit Polyclonal Antibody

Antibodies

Structural maintenance of chromosomes protein 1A (SMC1A) is involved in chromosome cohesion during cell cycle and in DNA repair. It is a central component of cohesin complex which is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Western Blot:A431 Cells, 1:500-1:5000

Type: Primary
Antigen: SMC1A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse

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