Anti-HIF1a Rabbit Polyclonal Antibody

Supplier: Proteintech
10088-244EA 402 USD
Anti-HIF1a Rabbit Polyclonal Antibody
HIF1, the major regulator of the cellular responses to hypoxia, consists of an oxygen-sensitive subunit, HIF1alpha (HIFA), and an oxygen-insensitive subunit, HIF1beta (arylhydrocarbon receptor nuclear transporter [ARNT]). Although the mRNA is constitutively and ubiquitously expressed and transcribed, the HIF1A protein is rapidly degraded in the presence of oxygen. The half-life of HIF1A under ambient oxygeconditions is less than 5 min. Both hypoxic conditions and chemical hydroxylase inhibitors (such as desferrioxamine and cobalt) inhibit HIF-1α degradation and lead to its stabilization. In addition, HIF-1α can be induced in an oxygen-independent manner by various cytokines through the PI3K-AKT-mTOR pathway.

IHC: Human thyroid cancer Tissue, 1:20-1:200; IF: Hela Cells, 1:10-1:100; Western Blot: HeLa Cells, 1:200-1:1000; FC: HeLa Cells, N/A

Type: Primary
Antigen: HIF1a
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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