Anti-FGD5 Rabbit Polyclonal Antibody

Supplier: Proteintech
10086-962EA 402 USD
Anti-FGD5 Rabbit Polyclonal Antibody
FGD5 (or ZFYVE23) is an endothelial specific gene, plays a crucial role in vascular pruning. Deficient expression of FGD5 markedly inhibits neovascularization, indicated by in vitro tube-formation, aortic-ring, and coated-bead assays and by in vivo coated-bead plug assays and studies in the murine retina model. FGD5-deficient endothelial cells fail to migrate. Moreover, the cells are susceptible to proapoptotic stimuli associated with VEGF-stimulated activation of Akt. FGD5 promotes apoptosis-induced vaso-obliteration via induction of the hey1-p53 pathway by direct binding and activation of CDC42.

Western Blot: Mouse Brain Tissue, 1:200-1:2000; IHC: Human lung, 1:20-1:200; IF: HepG2, 1:10-1:100

Type: Primary
Antigen: FGD5
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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