Anti-HMGA2 Rabbit Polyclonal Antibody

Supplier: Proteintech
10088-332EA 402 USD
Anti-HMGA2 Rabbit Polyclonal Antibody
HMGA2 belongs to the family of high mobility group with AT-hook DNA binding domain. HMGA proteins are considered architectural transcription factors; they do not have direct transcriptional activation capacity, but instead regulate gene expression by changing DNA conformation through binding to AT-rich regions in the DNA and/or direct interaction with other transcription factors (18202751,19551524). HMGA2 is abundantly and ubiquitously expressed and plays a crucial role during embryonic development (18425117). HMGA2 promotes stem cell self-renewal and research studies have shown that decreased HMGA2 expression is associated with stem cell aging (19551524). Investigators have shown that expression levels of HMGA2 are very low in normal adult tissues, while either overexpression or rearrangement is associated with many types of cancer (20228781).This antibody specifically reacts with 18kd HMGA2 protein.

Western Blot:NIH/3T3 Cells, 1:500-1:5000; IF:A549 Cells, 1:10-1:100

Type: Primary
Antigen: HMGA2
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
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