SHH, also named as HHG-1, belongs to the hedgehog family. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. It regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. SHH displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Defects in SHH are the cause of microphthalmia isolated with coloboma type 5 (MCOPCB5). Defects in SHH are the cause of holoprosencephaly type 3 (HPE3). Defects in SHH are a cause of solitary median maxillary central incisor (SMMCI). Defects in SHH are the cause of triphalangeal thumb-polysyndactyly syndrome (TPTPS). The antibody is specific to SHH.
Western Blot: Mouse Liver Tissue, 1:200-1:2000; IF: HepG2 Cells, 1:10-1:100; IHC: Mouse Kidney Tissue, 1:20-1:200
Type: Primary
Antigen: SHH
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
