Anti-PAWR Rabbit Polyclonal Antibody

Supplier: Proteintech
10090-932EA 402 USD
Anti-PAWR Rabbit Polyclonal Antibody
PAWR, also named as PAR4, is a pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. It induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. PAWR inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. It down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. PAWR may be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. The antibody is specific to PAWR.

Western Blot: Mouse Heart Tissue, 1:200-1:2000; IHC: Human breast cancer Tissue, 1:20-1:200

Type: Primary
Antigen: PAWR
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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