Anti-PERK Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-PERK Rabbit Polyclonal Antibody

Anti-PERK Rabbit Polyclonal Antibody

Anti-PERK Rabbit Polyclonal Antibody

Anti-PERK Rabbit Polyclonal Antibody

Anti-PERK Rabbit Polyclonal Antibody

Anti-PERK Rabbit Polyclonal Antibody

20582-1-AP-150UL

10092-102EA 537.7 USD

10092-102

Anti-PERK Rabbit Polyclonal Antibody

Antibodies

PERK, also named as EIF2AK3 and PEK, belongs to the protein kinase superfamily, Ser/Thr protein kinase family and GCN2 subfamily. PERK phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. PERK serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1. It catalyzes the reaction: ATP + a protein = ADP + a phosphoprotein. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS). The antibody is specific to PERK.

Western Blot:K-562 Cells, 1:500-1:5000; IHC: Human pancreas Tissue, 1:20-1:200

Type: Primary
Antigen: PERK
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human

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