Anti-DICER1 Rabbit Polyclonal Antibody

Supplier: Proteintech
10085-856EA 524.48 USD
Anti-DICER1 Rabbit Polyclonal Antibody
DICER1, also named as DICER, HERNA and KIAA0928, belongs to the helicase family and Dicer subfamily. It is required for formation of the RNA induced silencing complex (RISC). DICER1 is a component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. DICER1 cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs. The antibody is specific to DICER1.

Western Blot:K-562 Cells, 1:200-1:1000; IHC: Human Testis Tissue, 1:20-1:200; IF: HepG2 Cells, 1:10-1:100; IP:Jurkat Cells, 1:200-1:1000

Type: Primary
Antigen: DICER1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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