Anti-AXIN2 Rabbit Polyclonal Antibody

Supplier: Proteintech
10083-424EA 402 USD
Anti-AXIN2 Rabbit Polyclonal Antibody
Axis inhibition protein2 (AXIN2), also known as Coductin or Axil, is a multidoman scaffold protein that negatively regulate Wnt signaling. AXIN2 can directly interact with beta-catenin and GSK3B. AXIN2 has a number of phosphorylation sites, and also can undergo poly(ADP-ribosy)lation by tankyrase TNKS and TNKS2. Poly(ADP-ribosy)lated AXIN2 then get unbiquitinated by RNF146 and leads to its degradation and subsequent activation of Wnt signaling. AXIN2 is localized in the cytoplasm and its mutaion is involved in colorectal cancer. Catalgo#20540-1-AP is a rabbit polyclonal antibdy raised against a 34 amino acid N-terminal of human AXIN2.

Western Blot: Human Placenta Tissue, 1:200-1:2000

Type: Primary
Antigen: AXIN2
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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