Anti-RNF6 Rabbit Polyclonal Antibody

Supplier: Proteintech
10093-816EA 402 USD
Anti-RNF6 Rabbit Polyclonal Antibody
RNF6 was firstly cloned in a genetic study of chromosomal rearrangements in myeloproliferative disorders, mapping to chromosome 13q12.12 . It containing a coiled-coil domain at the N-terminus, and a RING-H2 finger at the C-terminus which is responsible for its ubiquitin ligase activity. It also activate Inha gene expression by participating in a protein complex binding to the promoter region . In addition, LIMK1 is a substrate of RNF6 and the RNF6-induced LIMK1 polyubiquitination is mediated via K48 of ubiquitin and leads to proteasomal degradation of the kinase .

Western Blot: Mouse Testis Tissue, 1:500-1:5000; IF: HepG2, 1:10-1:100

Type: Primary
Antigen: RNF6
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
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