Anti-EGLN1 Rabbit Polyclonal Antibody

Supplier: Proteintech
20368-1-AP-150UL
10081-360EA 402 USD
10081-360
Anti-EGLN1 Rabbit Polyclonal Antibody
Antibodies
EGLN1, also named as PHD2, SM-20, HPH-2 and HIF-PH2, catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. EGLN1 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Defects in EGLN1 are the cause of erythrocytosis familial type 3 (ECYT3). The antibody is specific to EGLN1.

Western Blot: HEK-293 Cells, 1:200-1:2000; IHC: Human pancreas Tissue, 1:20-1:200; IF: HepG2 Cells, 1:10-1:100

Type: Primary
Antigen: EGLN1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
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