Anti-CPLX2 Rabbit Polyclonal Antibody

Supplier: Proteintech
10082-044EA 402 USD
Anti-CPLX2 Rabbit Polyclonal Antibody
Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Neuronal specific complexin 1 (CPLX1) has inhibitory and stimulatory effects on exocytosis by clamping trans-SNARE complexes in a prefusion state and promoting conformational changes to facilitate membrane fusion following cell stimulation. Complexin2 (CPLX2) is a pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals, it is downregulated in schizophrenic patients suffering from depression, animal models of depression and neurological disorders such as Huntington's disease in which depression is a major symptom. This antibody is expected to specifically recogize CPLX2 but not other complexins.

Western Blot: Mouse Brain Tissue, 1:500-1:5000; IHC: Human Brain Tissue, 1:20-1:200

Type: Primary
Antigen: CPLX2
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
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