Anti-PTPN11 Rabbit Polyclonal Antibody

Supplier: Proteintech
10094-632EA 537.7 USD
Anti-PTPN11 Rabbit Polyclonal Antibody
PTPN11(protein tyrosine phosphatase, non-receptor type 11) is also named as PTP-1D, PTP2, PTP2C, PTP3, SHP2, CFC, CFC, BPTP3, SH-PTP2, SH-PTP3, MGC14433 and belongs to the protein-tyrosine phosphatase family and non-receptor class 2 subfamily. It modulates and regulates signaling through numerous pathways, many of which are active in the developing endocardial cushions and implicated the ERK pathway as a central mechanism. Its signaling may play equally important roles in retinal survival in both physiological and pathological conditions. Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1), Noonan syndrome type 1 (NS1), juvenile myelomonocytic leukemia (JMML) and metachondromatosis (MC). It has 3 isoforms produced by alternative splicing.

Western Blot:Jurkat Cells, 1:500-1:5000; IHC: Human breast cancer Tissue, 1:20-1:200; IF: Hela Cells, 1:10-1:100

Type: Primary
Antigen: PTPN11
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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