Anti-PAK2 Rabbit Polyclonal Antibody

Supplier: Proteintech
10091-760EA 402 USD
Anti-PAK2 Rabbit Polyclonal Antibody
PAK2, also named as PAK65, PAKgamma, p58, PAK-2p27, PAK-2p24 and C-t-PAK2, belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE20 subfamily. PAK2 acts on a variety of targets. PAK2 catalyzes the reaction: ATP + a protein = ADP + a phosphoprotein. PAK2 phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase-activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form. The antibody has no cross reaction to PAK1 and PAK3.

Western Blot: Human Skeletal Muscle Tissue, 1:500-1:5000; IHC: Human ovary, 1:20-1:200; IF: Hela, 1:10-1:100

Type: Primary
Antigen: PAK2
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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