Anti-RFWD3 Rabbit Polyclonal Antibody

Supplier: Proteintech
10093-602EA 402 USD
Anti-RFWD3 Rabbit Polyclonal Antibody
RFWD3, also named as RNF201, is a E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. RFWD3 may act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, It interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. From BLAST result, this antibody is specific to RFWD3. 45kd and 55kd maybe splicesome of RFWD3.

Western Blot: Mouse lung Tissue, 1:500-1:5000; IHC: Human Testis, 1:20-1:200; IF: Hela, 1:20-1:200

Type: Primary
Antigen: RFWD3
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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