Anti-APPL1 Rabbit Polyclonal Antibody

Supplier: Proteintech
10081-940EA 402 USD
Anti-APPL1 Rabbit Polyclonal Antibody
Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1), a binding partner of Akt2 and an important regulator of insulin signaling, plays a key role in the regulation of insulin secretion . APPL1 interacts with adiponectin receptors and mediates the insulin-sensitizing effects of adiponectin in muscle and endothelial cells. It also participates in nuclear signaling and transcriptional regulation, mostly by modulating the activity of various nuclear factors . Apart from its role in endocytosis and endosomal transport, APPL1 was reported to undergo nucleocytoplasmic shuttling and participate in transcriptional regulation, e.g. by interactions with histone deacetylases (HDACs) .

  • Western Blot: Human Brain Tissue, 1:1000-1:10000; IF: HepG2 Cells, 1:10-1:100; IHC: Human breast cancer Tissue, 1:20-1:200

Type: Primary
Antigen: APPL1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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