Anti-HIP1 Rabbit Polyclonal Antibody

Supplier: Proteintech
10088-260EA 402 USD
Anti-HIP1 Rabbit Polyclonal Antibody
HIP1 Belongs to the SLA2 family. HIP1 plays a role in clathrin-mediated endocytosis and trafficking. It is involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. It enhances androgen receptor (AR)-mediated transcription. HIP1 may act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. It binds 3-phosphoinositides (via ENTH domain). HIP1 may act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. HIP1 plays a functional role in the cell filament networks. It is required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). The antibody is specific to HIP1.

Western Blot:COLO 320 Cells, 1:500-1:5000; IHC: Human Brain, 1:20-1:200

Type: Primary
Antigen: HIP1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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