Anti-FANCD2 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-FANCD2 Rabbit Polyclonal Antibody

Anti-FANCD2 Rabbit Polyclonal Antibody

Anti-FANCD2 Rabbit Polyclonal Antibody

Anti-FANCD2 Rabbit Polyclonal Antibody

19543-1-AP-100UL

10086-856EA 304.98 USD

10086-856

Anti-FANCD2 Rabbit Polyclonal Antibody

Antibodies

FANCD2, also named as FACD and FACD2, is required for maintenance of chromosomal stability. FANCD2 promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. It may participate in S phase and G2 phase checkpoint activation upon DNA damage. It promotes BRCA2/FANCD1 loading onto damaged chromatin. FANCD2 may also be involved in B-cell immunoglobulin isotype switching. Defects in FANCD2 are a cause of Fanconi anemia (FA) which is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. The antibody is to phospho-Ser(330) of FANCD2.

Western Blot: HL-60 Cells, 1:200-1:2000; IHC: Human Testis Tissue, 1:20-1:200

Type: Primary
Antigen: FANCD2-phospho(S330)
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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