Anti-PKD2 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-PKD2 Rabbit Polyclonal Antibody

Anti-PKD2 Rabbit Polyclonal Antibody

Anti-PKD2 Rabbit Polyclonal Antibody

Anti-PKD2 Rabbit Polyclonal Antibody

Anti-PKD2 Rabbit Polyclonal Antibody

Anti-PKD2 Rabbit Polyclonal Antibody

Anti-PKD2 Rabbit Polyclonal Antibody

Anti-PKD2 Rabbit Polyclonal Antibody

19126-1-AP-150UL

10092-584EA 402 USD

10092-584

Anti-PKD2 Rabbit Polyclonal Antibody

Antibodies

Polycystin 2 (PKD2), the product of the gene mutated in type 2 autosomal dominant polycystic kidney disease, belongs to the polycystin family. PKD2 is a ~110-kDa six-transmembrane channel protein with cytoplasmic N- and C-termini. This protein functions as a Ca2+-activated intracellular Ca2+ release channel in the endoplasmic reticulum. It is also present in the plasma membrane, where it functions as a nonselective cation channel. In addition, PKD2 expression has been documented in the primary cilium of kidney epithelial cells, where it is believed to have an essential role in mediating Ca2+ entry in response to flow rate changes, suggesting that it may be part of a mechanosensing machinery residing in the primary cilium.

Western Blot: Human Kidney Tissue, 1:200-1:1000; IP: Mouse Testis Tissue, 1:200-1:2000

Type: Primary
Antigen: PKD2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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