Anti-ZCCHC11 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-ZCCHC11 Rabbit Polyclonal Antibody

Anti-ZCCHC11 Rabbit Polyclonal Antibody

Anti-ZCCHC11 Rabbit Polyclonal Antibody

Anti-ZCCHC11 Rabbit Polyclonal Antibody

18980-1-AP-150UL

10081-350EA 537.7 USD

10081-350

Anti-ZCCHC11 Rabbit Polyclonal Antibody

Antibodies

ZCCHC11, also named as KIAA0191 and TUT4, is an uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. ZCCHC11 catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. ZCCHC11 can’t bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28 and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. ZCCHC11 may also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP.This antibody is specifical to the 185 kd ZCCHCC11 protein.

Western Blot: MCF7 Cells, 1:200-1:2000; IF: HeLa Cells, 1:20-1:200; IP: MCF-7 Cells, 1:500-1:5000

Type: Primary
Antigen: ZCCHC11
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human

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