Anti-KIR2DL3 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-KIR2DL3 Rabbit Polyclonal Antibody

Anti-KIR2DL3 Rabbit Polyclonal Antibody

18966-1-AP-150UL

10089-268EA 402 USD

10089-268

Anti-KIR2DL3 Rabbit Polyclonal Antibody

Antibodies

Killer cell immunoglobulin-like receptors (KIRs) are a diverse family of inhibitory and activating receptors expressed on NK cells and a subset of T cells . These polymorphic receptors interact with specific motifs on HLA class I molecules, modulate NK cytolytic activity and are encoded by genes located on chromosome 19q13.4 . KIR2DL3, also known as CD158B2 or NKAT2, is an inhibitory receptor that is specific for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7) . It is a 341-amino acid transmembrane glycoprotein consisting of an extracellular region containing two C2-type Ig-like domains, a 19-amino acid hydrophobic transmembrane region, and a long cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory motifs (ITIMs). KIR2DL3 inhibits the cytolytic activity of NK cells thus preventing cell lysis .

Western Blot: Human Liver Tissue, 1:200-1:2000

Type: Primary
Antigen: KIR2DL3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human

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