Anti-DTX1 Rabbit Polyclonal Antibody

Supplier: Proteintech
10086-156EA 402 USD
Anti-DTX1 Rabbit Polyclonal Antibody
Deltex homolog 1 (E3 ubiquitin-protein ligase DTX1) is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.DTX1 is conserved from Drosophila, and is expressed in a wide array of tissues, particularly in the central nervous system, testes, and endothelial cells, mainly colocalized with Notch1.It contains a RING-type zinc finger and 2 WWE domains. This antibody recognizes DTX1 protein (72kd) and it's isoforms (about 60kd).

IF: Mouse olfactory epithelium Tissue, N/A; IHC: Human Testis Tissue, 1:20-1:200

Type: Primary
Antigen: DTX1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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