Anti-ERO1LB Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-ERO1LB Rabbit Polyclonal Antibody

Anti-ERO1LB Rabbit Polyclonal Antibody

Anti-ERO1LB Rabbit Polyclonal Antibody

Anti-ERO1LB Rabbit Polyclonal Antibody

18312-1-AP-150UL

10086-638EA 402 USD

10086-638

Anti-ERO1LB Rabbit Polyclonal Antibody

Antibodies

ERO1LB is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. It acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Glutathione may be required to regulate its activity in the endoplasmic reticulum. It may be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. It is required for the folding of cell, thereby being a source of oxidative stress. This antibody has no cross reaction to ERO1L.

Western Blot: Human Brain Tissue, 1:500-1:5000; IHC: Human pancreas Tissue, 1:20-1:200

Type: Primary
Antigen: ERO1LB
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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