Anti-HER2 Rabbit Polyclonal Antibody

Supplier: Proteintech
18299-1-AP-150UL
10086-598EA 453 USD
10086-598
Anti-HER2 Rabbit Polyclonal Antibody
Antibodies
HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase- mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas. This antibody is specific to HER2.

Western Blot: HeLa Cells, 1:1000-1:10000; IHC: Human breast cancer Tissue, 1:20-1:200; FC: MCF-7 Cells, N/A

Type: Primary
Antigen: HER2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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