Apoptosis-inducing factor (AIF) is one of the mitochondrial proteins to be released into the cytosol during apoptosis, and it is discovered as the first protein that regulates caspase-independent apoptosis. AIF is encoded as a 67 kDa protein that contains a mitochondrial localization signal (MLS) in the N-terminus.It is cleaved from the 62 kDa to the 57 kDa form following ischemic injury and translocated from the mitochondria to the nucleus in a calpain-dependent manner.
Western Blot:Jurkat Cells, 1:1000-1:10000; IHC: Human Kidney Tissue, 1:20-1:200; IP: HeLa Cells, 1:1000-1:10000; IF: HepG2 Cells, 1:10-1:100
Type: Primary
Antigen: AIF
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat