PJA1(E3 ubiquitin-protein ligase Praja-1), also named as RNF70, regulates the level of PRC2 (polycomb repressive complex 2) by targeting its free subunits for Ub-mediated proteasomal degradation and it can be involved in protein ubiquitination in the brain and is a suitable candidate gene for MRX. The Praja1 protein is unlikely to be a membrane receptor, since it lacks a hydrophobic transmembrane domain. It has 3 isoforms produced by alternative splicing with the molecular weight of 71 kDa, 50 kDa and 65 kDa.
Western Blot: Mouse Brain Tissue, 1:200-1:2000; IP: Mouse Brain Tissue, 1:200-1:1000
Type: Primary
Antigen: PJA1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat