MAGT1 is a mammalian Mg2+-selective transporter being required for cellular magnesium uptake and vertebrate embryonic development. It possesses five putative transmembrane (TM) regions with a cleavage site, a N-glycosylation site, and a number of phosphorylation sites. Western blot analysis revealed a 38-kD Magt1 protein in all mouse tissues as well as a 35-kD protein in some tissues.Recently mutations in MAGT1 has been found to be asscociated with a novel X-linked human immunodeficiency. The MAGT1 protein was undetectable in the patients’ cells by western blot or immunofluorescent cell surface staining(Nature 475, 471-6 ).
Western Blot:Jurkat Cells, 1:500-1:5000; IHC: Human Liver Tissue, 1:20-1:200; IF: HepG2 Cells, 1:10-1:100
Type: Primary
Antigen: MAGT1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat