Anti-RPAP2 Rabbit Polyclonal Antibody

Supplier: Proteintech
10093-880EA 402 USD
Anti-RPAP2 Rabbit Polyclonal Antibody
RPAP2 belongs to the RPAP family which were newly identified proteins named RNA Pol II-associated protein (RPAP), a set of proteins occupying key positions in the protein interaction network of the human Pol II machinery. Recently it has been reported that RPAP2 specifically and directly interacts with the Pol II CTD phosphorylated at Ser7. It can also dephosphorylate Ser5P of the CTD. During transcription of snRNA genes,Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5. RPAP2 is required for efficient transcription of snRNA genes by Pol II. siRNA-mediated knockdown of RPAP2 caused defects in snRNA gene expression.(22137580)

Western Blot: HEK-293 Cells, 1:500-1:5000

Type: Primary
Antigen: RPAP2
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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