Anti-NDEL1 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-NDEL1 Rabbit Polyclonal Antibody

Anti-NDEL1 Rabbit Polyclonal Antibody

17262-1-AP-150UL

10090-620EA 537.7 USD

10090-620

Anti-NDEL1 Rabbit Polyclonal Antibody

Antibodies

Nuclear distribution factor E-homolog 1 (NDE1), NDE-like 1 (NDEL1), and Lissencephaly 1 (LIS1) together involve in essential neurodevelopmental processes, including neuronal precursor proliferation and differentiation, neurite outgrowth, and neuronal migration. All three bind directly to Disrupted in Schizophrenia 1 (DISC1), a scaffold protein critical to neuronal proliferation, integration, migration, and synaptic function within the developing and adult brain. Nuclear distribution element-like 1 (NDEL1) was firstly identified as a regulator of the cytoskeleton in microtubule and intermediate fliament dynamics and microtubule-based transport . It is required for organization of the cellular microtubule array and microtubule anchoring at the centrosome, which is in part by targeting the microtubule severing protein KATNA1 to the centrosome.

Western Blot: Human Brain Tissue, 1:500-1:5000

Type: Primary
Antigen: NDEL1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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