CFHR3, also named as DOWN16, belongs to the complement factor H-related protein family. Expressed by the liver and secreted in plasma, human CFHR3 is composed of five short consensus repeats (SCRs), and it also has a 19-amino acid signal peptide and four N-linked glycosylation sites. It may be involved in complement regualtion. A frequent deletion of CFHR1 and CFHR3 genes was found to be associated with decrease risk of aged-related macular degeneration (AMD), and with an increased risk of atypical hemolytic-uremic syndrome (aHUS).
Western Blot: Human Heart Tissue, 1:500-1:5000; IHC: Human Liver, 1:20-1:200
Type: Primary
Antigen: CFHR3
Clonality: Polyclonal
Clone: 0
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: