Anti-AXIN1 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-AXIN1 Rabbit Polyclonal Antibody

Anti-AXIN1 Rabbit Polyclonal Antibody

16541-1-AP-150UL

10083-422EA 402 USD

10083-422

Anti-AXIN1 Rabbit Polyclonal Antibody

Antibodies

Axis inhibition protein1 (AXIN1), also called AXIN, together with AXIN2 are multidoman scaffold proteins that negatively regulate Wnt signaling. AXIN1 is likely to function as a tumor suppressor. Under UV irradiation, AXIN1-HIPK2-TP53 complex forms. The complex also controls cell growth, apoptosis and development. Like AXIN2, AXIN1 undergoes poly(ADP-ribosy)lation by tankyrase TNKS and TNKS2 followed by unbiquitination by RNF146 which leads to its degradation and subsequent activation of Wnt signaling. Its deubiquitination by USP34 is important for nuclear accumulation during Wnt signaling. Catalgo#16541-1-AP is a rabbit polyclonal antibdy raised against the N-terminal of human AXIN1.

Western Blot: HT-1080 Cells, 1:200-1:2000

Type: Primary
Antigen: AXIN1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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