Anti-NRF2, NFE2L2 Rabbit Polyclonal Antibody

Supplier: Proteintech
10091-298EA 537.7 USD
Anti-NRF2, NFE2L2 Rabbit Polyclonal Antibody
NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up- regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress .In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance. Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC.This antibody is a rabbit polyclonal antibody raised against the C-terminal amino acid residues (C-350 aa) of human NRF2 protein.

IP: Mouse Kidney Tissue, 1:200-1:1000; IHC: Human breast cancer Tissue, 1:20-1:200; Western Blot:DMSO treated HeLa Cells, 1:200-1:2000; FC: MCF-7 Cells, N/A

Type: Primary
Antigen: NRF2, NFE2L2
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
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