Anti-MCL1 Rabbit Polyclonal Antibody

Supplier: Proteintech
10090-036EA 402 USD
Anti-MCL1 Rabbit Polyclonal Antibody
MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target.

IHC: Human tonsillitis Tissue, 1:20-1:200; Western Blot: Raji Cells, 1:500-1:5000; IP: Raji Cells, 1:500-1:5000

Type: Primary
Antigen: MCL1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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