Anti-PLA2G12A Rabbit Polyclonal Antibody

Supplier: Proteintech
10092-412EA 402 USD
Anti-PLA2G12A Rabbit Polyclonal Antibody
PLA2G12A (or PLA2G12) gene encodes group XII secreted phospholipase A2 (sPLA2) which catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Cellular arachidonate (AA) release and prostaglandin (PG) production is regulated by sPLA(2)s, groups III and XII. Group XII sPLA2 have relatively low specific activity and are structurally and functionally distinct from other sPLA2s. Cells transfected with group XII sPLA(2) exhibited abnormal morphology, suggesting a unique functional aspect of this enzyme. Role of sPLA2s as potential tumour biomarkers and therapeutic targets for various cancers have been reported.

Western Blot: Mouse Skeletal Muscle Tissue, 1:500-1:5000; IHC: Human Colon cancer Tissue, 1:20-1:200

Type: Primary
Antigen: PLA2G12A
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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