Anti-PKM Rabbit Polyclonal Antibody

Supplier: Proteintech
10092-394EA 402 USD
Anti-PKM Rabbit Polyclonal Antibody
PKM2, also named as OIP3, PK2, PK3, PKM, p58, THBP1, CTHBP and Tumor M2-PK, belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM2 plays a general role in caspase independent cell death of tumor cells. PKM2, Pyruvate kinase isozymes M1/M2, has 2 isoforms .The immunogen of this antibody is M1 isoform, also called PKM1. By the upstream metabolite fructose-1,6-bisphosphate, PKM1 is a constitutively active enzyme.The primary pyruvate kinase isoform before tumour development is PK-M1; however, the primary isoform from four independent tumours is PK-M2. This antibody is specific to PKM1 isoform.

Western Blot: Mouse Skeletal Muscle Tissue, 1:500-1:5000; IHC: Human Skeletal Muscle Tissue, 1:20-1:200; IP: Mouse Brain Tissue, 1:500-1:5000; IF: HeLa Cells, 1:20-1:200

Type: Primary
Antigen: PKM
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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