Anti-CITED2 Rabbit Polyclonal AntibodySupplier: Proteintech
10084-610EA 402 USD10084-610
Anti-CITED2 Rabbit Polyclonal Antibody
CITED2 is a cAMP-responsive element-binding protein (CBP)/p300-transactivator, with an ED(Glu/Asp)-rich C-terminal domain that acts as an important modulator in the development of the heart . It is proposed to be a negative regulator of HIF-1α through its competitive binding to the CH1 domain of CBP/p300, which mediated signaling and to a decrease in HIF-1-responsive genes such as VEGF . In addition, it is also a co-activator of the transcriptional activity of the TFAP2 isoform, which is an extensively expressed nuclear protein with functions in embryogenesis, inflammation, and stress responses.
Western Blot:SH-SY5Y Cells, 1:200-1:2000
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