Anti-PPP1R15B Rabbit Polyclonal Antibody

Supplier: Proteintech
10092-690EA 537.7 USD
Anti-PPP1R15B Rabbit Polyclonal Antibody
Protein phosphatase 1 regulatory subunit 15B(PPP1R15B) is a member of PPP1R15 family, it forms a complex with protein phosphatase1(PP1) and NCK1/2, maintaining low levels of EIF2S1 phosporylation in unstressed cells, thus is also named constitutive repressor of eIF2alpha phosphorylation (CReP). PPP1R15B is assoicated in endoplasmic reticulum (ER) stress response resulting to a role in translation regulation. Knock-down of PPP1R15B strongly protected mammalian cells against oxidative stress, peroxynitrite stress, and more modestly against accumulation of malfolded proteins in the ER. Recently, PPP1R15B was found to associate with cell membranes and regulate membrane traffic in a PP1c-independent manner, suggesting a novel link between translation and traffic.

Western Blot:SGC-7901 Cells, 1:500-1:5000; IHC: Human ovary Tissue, 1:20-1:200; IF: HepG2 Cells, 1:20-1:200; IP: MCF-7 Cells, 1:500-1:5000

Type: Primary
Antigen: PPP1R15B
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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